human GRINL1A shRNA silencing AAV

Name
AAV-h-GRINL1A-shRNA

Cat No
shAAV-229837

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human POLR2M.

shAAV-229837

AAV-h-GRINL1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLR2M (RNA polymerase II subunit M). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GCOM1; Gdown; Gdown1; GRINL1A

Description (Vector)

POLR2M encodes a subunit of RNA polymerase II, a protein complex that is responsible for synthesizing messenger RNA in eukaryotes. The encoded protein functions as a component of a specific form of RNA polymerase II termed Pol II(G). This protein may act as a negative regulator of activator-dependent transcription. Alternate splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein).

Gene ID

81488

Gene Name (Vector)

RNA polymerase II subunit M

Gene Symbol

POLR2M

HGNC ID

HGNC:14862

ORF Size (aa)

1107

ORF Size (bp)

1107 bp

RefSeq ID

NM_015532

RefSeq Synonyms

NM_015532, NM_001018102, BC001510,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.