human ARHGAP8 shRNA silencing AAV

Name
AAV-h-ARHGAP8-shRNA

Cat No
shAAV-229574

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ARHGAP8.

shAAV-229574

AAV-h-ARHGAP8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGAP8 (Rho GTPase activating protein 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BPGAP1; PP610

Description (Vector)

ARHGAP8 encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Gene ID

23779

Gene Name (Vector)

Rho GTPase activating protein 8

Gene Symbol

ARHGAP8

HGNC ID

HGNC:677

ORF Size (aa)

1302

ORF Size (bp)

1302 bp

RefSeq ID

NM_001017526

RefSeq Synonyms

NM_181335, NM_001198726, NM_001017526, BC048280,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.