human XRCC1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human XRCC1.
shAAV-227923
AAV-h-XRCC1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human XRCC1 (X-ray repair cross complementing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1
Description (eCommerce)
X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.
Description (Vector)
XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Gene ID
7515
Gene Name (eCommerce)
X-ray repair cross complementing 1
Gene Name (Vector)
X-ray repair cross complementing 1
Gene Symbol
XRCC1
HGNC ID
HGNC:12828
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1902
ORF Size (bp)
1902 bp
Protein Name (eCommerce)
DNA repair protein XRCC1
RefSeq ID
NM_006297
RefSeq Synonyms
NM_006297, BC023593,
Research Areas
DNA Damage/Repair,Hypoxia,Phospho-specific
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.
UniGene ID
Hs.98493
UniProt ID (eCommerce)
P18887
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.