human WRB shRNA silencing AAV

Name
AAV-h-WRB-shRNA

Cat No
shAAV-227843

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human WRB.

shAAV-227843

AAV-h-WRB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human WRB (tryptophan rich basic protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CHD5; GET1

Description (Vector)

WRB encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

7485

Gene Name (Vector)

tryptophan rich basic protein

Gene Symbol

WRB

HGNC ID

HGNC:12790

ORF Size (aa)

525

RefSeq ID

NM_004627

RefSeq Synonyms

NM_004627, NM_001146218, BC012415,

Species

human

UniGene ID

Hs.198308

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.