human WNT3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WNT3.
shAAV-227824
AAV-h-WNT3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WNT3 (Wnt family member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
INT4; TETAMS
Description (Vector)
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
Gene ID
7473
Gene Name (Vector)
Wnt family member 3
Gene Symbol
WNT3
HGNC ID
HGNC:12782
ORF Size (aa)
1068
RefSeq ID
NM_030753
RefSeq Synonyms
NM_030753, BC114219, BC112118, BC112116, BC111600,
Species
human
UniGene ID
Hs.445884
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.