human WASL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WASL.
shAAV-227602
AAV-h-WASL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WASL (Wiskott-Aldrich syndrome like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
N-WASP; NWASP; WASPB
Description (Vector)
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
Gene ID
8976
Gene Name (Vector)
Wiskott-Aldrich syndrome like
Gene Symbol
WASL
HGNC ID
HGNC:12735
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
RefSeq ID
NM_003941
RefSeq Synonyms
NM_003941, BC052955,
Species
human
UniGene ID
Hs.708402
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.