human VAPB shRNA silencing AAV

Name 
AAV-h-VAPB-shRNA
Cat No 
shAAV-227394
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human VAPB.

shAAV-227394
AAV-h-VAPB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human VAPB (VAMP associated protein B and C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALS8; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated 33 kDa protein; VAMP-associated protein B/C; VAMP-B; VAMP-B/VAMP-C; VAP-B; VAP-B/VAP-C; vesicle-associated membrane protein-associated protein B/C
Description (eCommerce)
Vesicle-associated membrane protein-associated protein B/C (VAPB) is a type IV membrane protein found in plasma and intracellular vesicle membranes and may play a role in vesicle trafficking. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8. ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type (SMAF), also called late-onset spinal muscular atrophy Finkel type or spinal muscular atrophy proximal adult autosomal dominant [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95292].
Description (Vector)
VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Gene ID
9217
Gene Name (eCommerce)
VAMP associated protein B and C
Gene Name (Vector)
VAMP associated protein B and C
Gene Symbol
VAPB
HGNC ID
HGNC:12649
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
732
Protein Name (eCommerce)
Vesicle-associated membrane protein-associated protein B/C
RefSeq ID
NM_004738
RefSeq Synonyms
NM_004738, NM_001195677, BC001712,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Golgi Apparatus,Host-Virus Interactions,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Protein Folding,Transport
Research Areas (Faceted)
neurobiology,cell_biology,infectious_disease,metabolism,neurobiology,cell_biology
Species
human
Target Sentence
Vesicle-associated membrane protein-associated protein B/C (VAPB) is a type IV membrane protein found in plasma and intracellular vesicle membranes and may play a role in vesicle trafficking. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8. ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type (SMAF), also called late-onset spinal muscular atrophy Finkel type or spinal muscular atrophy proximal adult autosomal dominant [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95292].
UniGene ID
Hs.182625
UniProt ID (eCommerce)
O95292

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.