human USP3 shRNA silencing AAV

Name 
AAV-h-USP3-shRNA
Cat No 
shAAV-227303
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human USP3.

shAAV-227303
AAV-h-USP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human USP3 (ubiquitin specific peptidase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
deubiquitinating enzyme 3; SIH003; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin thioesterase 3; ubiquitin thiolesterase 3; ubiquitin-specific-processing protease 3; UBP
Description (eCommerce)
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 3 (USP3) is a member of this family and is involved in the deubiquitination of histones H2A and H2B.
Gene ID
9960
Gene Name (eCommerce)
ubiquitin specific peptidase 3
Gene Name (Vector)
ubiquitin specific peptidase 3
Gene Symbol
USP3
HGNC ID
HGNC:12626
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1563
ORF Size (bp)
1563 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase 3
RefSeq ID
NM_006537
RefSeq Synonyms
NM_006537, NM_001256702, BC107138, BC107137, BC065300, BC018113,
Research Areas
Cell Cycle,DNA Damage/Repair,Histone Modification,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 3 (USP3) is a member of this family and is involved in the deubiquitination of histones H2A and H2B.
UniGene ID
Hs.458499
UniProt ID (eCommerce)
Q9Y6I4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.