human UPK1B shRNA silencing AAV

Cat. No: shAAV-227230

Availability: 6-8 weeks

Name: AAV-h-UPK1B-shRNA

This is an AAV expressing shRNA for silencing of Human UPK1B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UPK1B
Gene Name: uroplakin 1B
Gene ID: 7348
Gene Synonyms: TSPAN20; UPIB; UPK1
ORF Size: 783 bp
RefSeq#: NM_006952
Gene Description: UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.
UniGene ID: Hs.271580
HGNC ID: HGNC:12578