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human UCHL5 shRNA silencing AAV

Name 
AAV-h-UCHL5-shRNA
Cat No 
shAAV-227104
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UCHL5.

shAAV-227104
AAV-h-UCHL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UCHL5 (ubiquitin C-terminal hydrolase L5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CGI-70; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5; UCH37; UCH-L5
Description (eCommerce)
Ubiquitin C-terminal hydrolase UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. UCH37 is a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. It is a putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K5].
Gene ID
51377
Gene Name (eCommerce)
ubiquitin C-terminal hydrolase L5
Gene Name (Vector)
ubiquitin C-terminal hydrolase L5
Gene Symbol
UCHL5
HGNC ID
HGNC:19678
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
987
ORF Size (bp)
987 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase isozyme L5
RefSeq ID
NM_015984
RefSeq Synonyms
NM_015984, NM_001199263, NM_001199262, NM_001199261, BC025369, BC015521,
Research Areas
Brain Development,Cardiology,Cardiovascular,Complexome,DNA Damage/Repair,Neurobiology,Neurodevelopment,Proteasome,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,cell_biology,genetics,transcription_translation,neurobiology,developmental_biology,cell_biology,signal_transduction,immunology,genetics,transcription_translation
Species
human
Target Sentence
Ubiquitin C-terminal hydrolase UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. UCH37 is a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. It is a putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K5].
UniGene ID
Hs.591458
UniProt ID (eCommerce)
Q9Y5K5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.