human UBXN4 shRNA silencing AAV

Name 
AAV-h-UBXN4-shRNA
Cat No 
shAAV-227096
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBXN4.

shAAV-227096
AAV-h-UBXN4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBXN4 (UBX domain protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
erasin; UBX domain containing 2; UBX domain-containing 1; UBX domain-containing protein 2; UBX domain-containing protein 4; UBXD2; UBXDC1
Description (eCommerce)
UBX domain-containing protein 4 (UBXN4) is Involved in endoplasmic reticulum-associated protein degradation (ERAD). It acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92575].
Description (Vector)
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 (PubMed 16968747)).(supplied by OMIM, Mar 2008)
Gene ID
23190
Gene Name (eCommerce)
UBX domain protein 4
Gene Name (Vector)
UBX domain protein 4
Gene Symbol
UBXN4
HGNC ID
HGNC:14860
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1527
ORF Size (bp)
1527 bp
Protein Name (eCommerce)
UBX domain-containing protein 4
RefSeq ID
NM_014607
RefSeq Synonyms
NM_014607, BC035594, BC020806,
Research Areas
Protein Folding
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
UBX domain-containing protein 4 (UBXN4) is Involved in endoplasmic reticulum-associated protein degradation (ERAD). It acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92575].
UniGene ID
Hs.591242
UniProt ID (eCommerce)
Q92575

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.