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human UBR5 shRNA silencing AAV

Name 
AAV-h-UBR5-shRNA
Cat No 
shAAV-227080
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBR5.

shAAV-227080
AAV-h-UBR5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DD5; E3 identified by differential display; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; HECT-type E3 ubiquitin transferase UBR5; hHYD; HYD; hyperplastic discs protein homolog; progestin-induced protein
Description (eCommerce)
EDD1 (E3 identified by differential display 1) is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis [taken from NCBI Entrez Gene (Gene ID: 51366)].
Description (Vector)
UBR5 encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. UBR5 is localized to chromosome 8q22 which is disrupted in a variety of cancers. UBR5 potentially has a role in regulation of cell proliferation or differentiation.
Gene ID
51366
Gene Name (eCommerce)
ubiquitin protein ligase E3 component n-recognin 5
Gene Name (Vector)
ubiquitin protein ligase E3 component n-recognin 5
Gene Symbol
UBR5
HGNC ID
HGNC:16806
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
8400
ORF Size (bp)
8400 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase UBR5
RefSeq ID
NM_015902
RefSeq Synonyms
NM_015902, NM_001282873, BC137234,
Research Areas
DNA Damage/Repair,Histone Modification,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
EDD1 (E3 identified by differential display 1) is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis [taken from NCBI Entrez Gene (Gene ID: 51366)].
UniGene ID
Hs.591856
UniProt ID (eCommerce)
O95071

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.