human UBQLN2 shRNA silencing AAV

Name 
AAV-h-UBQLN2-shRNA
Cat No 
shAAV-227071
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBQLN2.

shAAV-227071
AAV-h-UBQLN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBQLN2 (ubiquilin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALS15; CHAP1; DSK2; DSK2 homolog; hPLIC-2; HRIHFB2157; N4BP4; Nedd4 binding protein 4; PLIC2; PLIC-2; protein linking IAP with cytoskeleton 2; ubiquilin-2; ubiquitin-like product Chap1/Dsk2
Description (eCommerce)
Ubiquilin-2 (UBXLN2) is a ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein [taken from NCBI Entrez Gene (Gene ID: 29978)].
Description (Vector)
UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
Gene ID
29978
Gene Name (eCommerce)
ubiquilin 2
Gene Name (Vector)
ubiquilin 2
Gene Symbol
UBQLN2
HGNC ID
HGNC:12509
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1875
ORF Size (bp)
1875 bp
Protein Name (eCommerce)
Ubiquilin-2
RefSeq ID
NM_013444
RefSeq Synonyms
NM_013444, BC069237,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Neurobiology,Neurodegeneration
Research Areas (Faceted)
neurobiology,cell_biology
Species
human
Target Sentence
Ubiquilin-2 (UBXLN2) is a ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein [taken from NCBI Entrez Gene (Gene ID: 29978)].
UniGene ID
Hs.179309
UniProt ID (eCommerce)
Q9UHD9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.