human UBA2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human UBA2.
shAAV-226961
AAV-h-UBA2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human UBA2 (ubiquitin like modifier activating enzyme 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
anthracycline-associated resistance ARX; ARX; HRIHFB2115; SAE2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1 homolog; ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2
Description (eCommerce)
SAE2 (SUMO-activating enzyme subunit 2) is also known as UBA2 (ubiquitin-like modifier activating enzyme 2). Heterodimers of SAE1 and SAE2 act as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. Heterodimers mediate ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UBT2].
Description (Vector)
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 (PubMed 9920803)).(supplied by OMIM, Mar 2010)
Gene ID
10054
Gene Name (eCommerce)
ubiquitin like modifier activating enzyme 2
Gene Name (Vector)
ubiquitin like modifier activating enzyme 2
Gene Symbol
UBA2
HGNC ID
HGNC:30661
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1923
ORF Size (bp)
1923 bp
Protein Name (eCommerce)
SUMO-activating enzyme subunit 2
RefSeq ID
NM_005499
RefSeq Synonyms
NM_005499, BC003153,
Research Areas
Cell Cycle,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SAE2 (SUMO-activating enzyme subunit 2) is also known as UBA2 (ubiquitin-like modifier activating enzyme 2). Heterodimers of SAE1 and SAE2 act as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. Heterodimers mediate ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UBT2].
UniGene ID
Hs.631580
UniProt ID (eCommerce)
Q9UBT2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.