human TRPM5 shRNA silencing AAV

Name
AAV-h-TRPM5-shRNA

Cat No
shAAV-226555

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TRPM5.

shAAV-226555

AAV-h-TRPM5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRPM5 (transient receptor potential cation channel subfamily M member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LTRPC5; MTR1

Description (Vector)

TRPM5 encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. TRPM5 is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele.

Gene ID

29850

Gene Name (Vector)

transient receptor potential cation channel subfamily M member 5

Gene Symbol

TRPM5

HGNC ID

HGNC:14323

ORF Size (aa)

3498

ORF Size (bp)

3498 bp

RefSeq ID

NM_014555

RefSeq Synonyms

NM_014555, BC143353, BC143351, BC093789, BC093787,

Species

human

UniGene ID

Hs.272287

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.