human TRIM5 shRNA silencing AAV

Cat. No: shAAV-226451

Availability: 4-5 weeks

Name: AAV-h-TRIM5-shRNA

This is an AAV expressing shRNA for silencing of Human TRIM5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TRIM5
Gene Name: tripartite motif containing 5
Gene ID: 85363
Gene Synonyms: RNF88; TRIM5alpha
ORF Size: 1044 bp
RefSeq#: NM_033034
Gene Description: TRIM5 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.370515
HGNC ID: HGNC:16276