Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human TPR shRNA silencing AAV

Name 
AAV-h-TPR-shRNA
Cat No 
shAAV-226289
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TPR.

shAAV-226289
AAV-h-TPR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TPR (translocated promoter region, nuclear basket protein). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
megator; NPC-associated intranuclear protein; nuclear pore complex-associated protein TPR; nucleoprotein TPR; translocated promoter region (to activated MET oncogene); translocated promoter region protein; tumor potentiating region
Description (eCommerce)
TPR (translocated promoter region) was identified in oncogenic fusions with the kinase domains of trk, met, and raf protooncogenes. TPR has also been identified as a candidate nuclear skeletal protein that localizes to nuclear pore-associated intranuclear filaments. TPR is part of an interchromasomal channel-based nuclear matrix that provides connectivity between the nuclear interior and periphery. It is implicated in intranuclear transport and export of mRNA and proteins.
Description (Vector)
TPR encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.
Gene ID
7175
Gene Name (eCommerce)
translocated promoter region, nuclear basket protein
Gene Name (Vector)
translocated promoter region, nuclear basket protein
Gene Symbol
TPR
HGNC ID
HGNC:12017
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7089
ORF Size (bp)
7089 bp
Protein Name (eCommerce)
Nucleoprotein TPR
RefSeq ID
NM_003292
RefSeq Synonyms
NM_003292, BC156389,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Nuclear Import/Export,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Translational Control,Transport
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,metabolism,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
TPR (translocated promoter region) was identified in oncogenic fusions with the kinase domains of trk, met, and raf protooncogenes. TPR has also been identified as a candidate nuclear skeletal protein that localizes to nuclear pore-associated intranuclear filaments. TPR is part of an interchromasomal channel-based nuclear matrix that provides connectivity between the nuclear interior and periphery. It is implicated in intranuclear transport and export of mRNA and proteins.
UniGene ID
Hs.279640
UniProt ID (eCommerce)
P12270

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.