human TPP2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TPP2.
shAAV-226284
AAV-h-TPP2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TPP2 (tripeptidyl peptidase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TPP-2; TPPII; TPP-II; tripeptidyl aminopeptidase; tripeptidyl-peptidase 2; tripeptidyl-peptidase II
Description (eCommerce)
Tripeptidyl aminopeptidase is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29144].
Description (Vector)
TPP2 encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.
Gene ID
7174
Gene Name (eCommerce)
tripeptidyl peptidase 2
Gene Name (Vector)
tripeptidyl peptidase 2
Gene Symbol
TPP2
HGNC ID
HGNC:12016
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3750
ORF Size (bp)
3750 bp
Protein Name (eCommerce)
Tripeptidyl-peptidase 2
RefSeq ID
NM_003291
RefSeq Synonyms
NM_003291, NM_001330588, BC039905,
Research Areas
Antigen Processing and Presentation,Immunology
Research Areas (Faceted)
immunology
Species
human
Target Sentence
Tripeptidyl aminopeptidase is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29144].
UniGene ID
Hs.432424
UniProt ID (eCommerce)
P29144
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.