human TPH2 shRNA silencing AAV

Name
AAV-h-TPH2-shRNA

Cat No
shAAV-226258

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TPH2.

shAAV-226258

AAV-h-TPH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TPH2 (tryptophan hydroxylase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADHD7; NTPH

Description (Vector)

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. TPH2 is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene ID

121278

Gene Name (Vector)

tryptophan hydroxylase 2

Gene Symbol

TPH2

HGNC ID

HGNC:20692

ORF Size (aa)

1491

ORF Size (bp)

1491 bp

RefSeq ID

NM_173353

RefSeq Synonyms

NM_173353, BC114499, BC114442,

Species

human

UniGene ID

Hs.376337

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.