human TPBG shRNA silencing AAV

Name
AAV-h-TPBG-shRNA

Cat No
shAAV-226243

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TPBG.

shAAV-226243

AAV-h-TPBG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TPBG (trophoblast glycoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

5T4; 5T4AG; M6P1; WAIF1

Description (Vector)

TPBG encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.

Gene ID

7162

Gene Name (Vector)

trophoblast glycoprotein

Gene Symbol

TPBG

HGNC ID

HGNC:12004

ORF Size (aa)

1263

ORF Size (bp)

1263 bp

RefSeq ID

NM_006670

RefSeq Synonyms

NM_006670, NM_001166392, BC037161,

Species

human

UniGene ID

Hs.82128

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.