human TOP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TOP1.
shAAV-226200
AAV-h-TOP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TOP1 (topoisomerase (DNA) I). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA topoisomerase 1; DNA topoisomerase I; TOPI; topoisomerase (DNA) I; type I DNA topoisomerase
Description (eCommerce)
Topoisomerase I (TOPI) functions as an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA [taken from NCBI Entrez Gene (GeneID: 7150)].
Description (Vector)
TOP1 encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. TOP1 is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Gene ID
7150
Gene Name (eCommerce)
DNA topoisomerase I
Gene Name (Vector)
topoisomerase (DNA) I
Gene Symbol
TOP1
HGNC ID
HGNC:11986
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2298
ORF Size (bp)
2298 bp
Protein Name (eCommerce)
DNA topoisomerase 1
RefSeq ID
NM_003286
RefSeq Synonyms
NM_003286, BC136297,
Research Areas
Apoptosis,Cancer,Cell Cycle,Chromatin Remodeling,DNA Replication,Host-Virus Interactions,Replication,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Topoisomerase I (TOPI) functions as an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA [taken from NCBI Entrez Gene (GeneID: 7150)].
UniGene ID
Hs.472737
UniProt ID (eCommerce)
P11387
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.