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human TNNI2 shRNA silencing AAV

Name 
AAV-h-TNNI2-shRNA
Cat No 
shAAV-226131
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TNNI2.

shAAV-226131
AAV-h-TNNI2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TNNI2 (troponin I2, fast skeletal type). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AMCD2B;DA2B;FSSV;fsTnI;troponin I fast twitch 2;troponin I type 2 (skeletal, fast);troponin I, fast skeletal muscle;troponin I, fast-twitch isoform;troponin I, fast-twitch skeletal muscle isoform;troponin I, skeletal, fast
Description (eCommerce)
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
Description (Vector)
TNNI2 encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Gene ID
7136
Gene Name (eCommerce)
troponin I2, fast skeletal type
Gene Name (Vector)
troponin I2, fast skeletal type
Gene Symbol
TNNI2
HGNC ID
HGNC:11946
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
549
Protein Name (eCommerce)
Troponin I, fast skeletal muscle
RefSeq ID
NM_003282
RefSeq Synonyms
NM_003282, NM_001145841, NM_001145829, BC032148,
Research Areas
Cell Biology, Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The Troponin I subfamily contains three genes: Troponin I-skeletal-fast-twitch, Troponin I-skeletal-slow-twitch, and Troponin I-cardiac. Troponin I-cardiac is exclusively expressed in cardiac muscle tissues. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P19429].
UniGene ID
Hs.523403
UniProt ID (eCommerce)
P48788

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.