human TNK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TNK2.
shAAV-226121
AAV-h-TNK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TNK2 (tyrosine kinase non receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACK; ACK-1; ACK1; p21cdc42Hs
Description (Vector)
TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Gene ID
10188
Gene Name (Vector)
tyrosine kinase non receptor 2
Gene Symbol
TNK2
HGNC ID
HGNC:19297
ORF Size (aa)
3117
ORF Size (bp)
3117 bp
RefSeq ID
NM_005781
RefSeq Synonyms
NM_005781, NM_001308046, NM_001010938, BC156798, BC028164,
Species
human
UniGene ID
Hs.518513
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.