human TMUB1 shRNA silencing AAV

Name 
AAV-h-TMUB1-shRNA
Cat No 
shAAV-226044
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMUB1.

shAAV-226044
AAV-h-TMUB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMUB1 (transmembrane and ubiquitin like domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C7orf21; dendritic cell-derived ubiquitin-like protein; DULP; hepatocyte odd protein shuttling protein; SB144; transmembrane and ubiquitin-like domain-containing protein 1; ubiquitin-like protein DULP; ubiquitin-like protein SB144
Description (eCommerce)
Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). It is involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity) and acts as negative regulator of hepatocyte growth during regeneration (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BVT8].
Gene ID
83590
Gene Name (eCommerce)
transmembrane and ubiquitin like domain containing 1
Gene Name (Vector)
transmembrane and ubiquitin like domain containing 1
Gene Symbol
TMUB1
HGNC ID
HGNC:21709
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
741
ORF Size (bp)
741 bp
Protein Name (eCommerce)
Transmembrane and ubiquitin-like domain-containing protein 1
RefSeq ID
NM_031434
RefSeq Synonyms
NM_031434, NM_001136044, BC033182, BC000936,
Research Areas
Cell Biology,Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). It is involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity) and acts as negative regulator of hepatocyte growth during regeneration (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BVT8].
UniGene ID
Hs.647096
UniProt ID (eCommerce)
Q9BVT8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.