human TLE2 shRNA silencing AAV

Name
AAV-h-TLE2-shRNA

Cat No
shAAV-225564

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TLE2.

shAAV-225564

AAV-h-TLE2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TLE2 (transducin like enhancer of split 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

enhancer of split groucho-like protein 2; ESG; ESG2; GRG2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2

Description (eCommerce)

Transducin-like enhancer protein 2 (TLE2) transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q04725].

Gene ID

7089

Gene Name (eCommerce)

transducin like enhancer of split 2

Gene Name (Vector)

transducin like enhancer of split 2

Gene Symbol

TLE2

HGNC ID

HGNC:11838

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2232

ORF Size (bp)

2232 bp

Protein Name (eCommerce)

Transducin-like enhancer protein 2

RefSeq ID

NM_003260

RefSeq Synonyms

NM_003260, NM_001300846, NM_001144762, NM_001144761, BC017364,

Research Areas

Cancer,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

Transducin-like enhancer protein 2 (TLE2) transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q04725].

UniGene ID

Hs.332173

UniProt ID (eCommerce)

Q04725

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.