human TK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TK2.
shAAV-225551
AAV-h-TK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TK2 (thymidine kinase 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MTDPS2; MTTK; PEOB3; SCA31
Description (Vector)
TK2 encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants.
Gene ID
7084
Gene Name (Vector)
thymidine kinase 2, mitochondrial
Gene Symbol
TK2
HGNC ID
HGNC:11831
ORF Size (aa)
651
RefSeq ID
NM_004614
RefSeq Synonyms
NM_004614, NM_001272050, NM_001271935, NM_001271934, NM_001172645, NM_001172644, NM_001172643, BC142970,
Species
human
UniGene ID
Hs.512619
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.