human THOP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human THOP1.
shAAV-225458
AAV-h-THOP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human THOP1 (thimet oligopeptidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
endopeptidase 24.15; EP24.15; MEPD_HUMAN; MP78; thimet oligopeptidase; TOP
Description (eCommerce)
Thimet oligopeptidase (THOP1) is a kininase that uses zinc as a cofactor. THOP1 cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides [taken from NCBI Entrez Gene (Gene ID: 7064)].
Gene ID
7064
Gene Name (eCommerce)
thimet oligopeptidase 1
Gene Name (Vector)
thimet oligopeptidase 1
Gene Symbol
THOP1
HGNC ID
HGNC:11793
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2070
ORF Size (bp)
2070 bp
Protein Name (eCommerce)
Thimet oligopeptidase
RefSeq ID
NM_003249
RefSeq Synonyms
NM_003249, BC013878, BC002391, BC000135,
Research Areas
Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Thimet oligopeptidase (THOP1) is a kininase that uses zinc as a cofactor. THOP1 cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides [taken from NCBI Entrez Gene (Gene ID: 7064)].
UniGene ID
Hs.78769
UniProt ID (eCommerce)
P52888
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.