human TFAP4 shRNA silencing AAV

Name 
AAV-h-TFAP4-shRNA
Cat No 
shAAV-225350
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TFAP4.

shAAV-225350
AAV-h-TFAP4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TFAP4 (transcription factor AP-4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
activating enhancer-binding protein 4; AP-4; bHLHc41; class C basic helix-loop-helix protein 41; transcription factor AP-4; transcription factor AP-4 (activating enhancer binding protein 4)
Description (eCommerce)
AP4 is a basic helix-loop-helix-zipper (bHLH-ZIP) transcription factor. BHLH-ZIP transcription factors contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG [taken from NCBI Entrez Gene (GeneID: 7023)].
Description (Vector)
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed 2833704); Hu et al., 1990 (PubMed 2123466)).(supplied by OMIM, Jul 2009)
Gene ID
7023
Gene Name (eCommerce)
transcription factor AP-4
Gene Name (Vector)
transcription factor AP-4
Gene Symbol
TFAP4
HGNC ID
HGNC:11745
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1017
Protein Name (eCommerce)
Transcription factor AP-4
RefSeq ID
NM_003223
RefSeq Synonyms
NM_003223, BC010576,
Research Areas
Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
AP4 is a basic helix-loop-helix-zipper (bHLH-ZIP) transcription factor. BHLH-ZIP transcription factors contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG [taken from NCBI Entrez Gene (GeneID: 7023)].
UniGene ID
Hs.513305
UniProt ID (eCommerce)
Q01664

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.