human TDO2 shRNA silencing AAV

Name
AAV-h-TDO2-shRNA

Cat No
shAAV-225263

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TDO2.

shAAV-225263

AAV-h-TDO2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TDO2 (tryptophan 2,3-dioxygenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TDO; TO; TPH2; TRPO

Description (Vector)

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene ID

6999

Gene Name (Vector)

tryptophan 2,3-dioxygenase

Gene Symbol

TDO2

HGNC ID

HGNC:11708

ORF Size (aa)

1221

ORF Size (bp)

1221 bp

RefSeq ID

NM_005651

RefSeq Synonyms

NM_005651, BC005355,

Species

human

UniGene ID

Hs.183671

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.