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human TCP1 shRNA silencing AAV

Name 
AAV-h-TCP1-shRNA
Cat No 
shAAV-225239
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TCP1.

shAAV-225239
AAV-h-TCP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TCP1 (t-complex 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CCT1; CCTa; CCT-alpha; D6S230E; tailless complex polypeptide 1; t-complex 1 protein; T-complex protein 1 subunit alpha; T-complex protein 1, alpha subunit; TCP-1-alpha
Description (eCommerce)
T-complex protein 1 subunit alpha (TCP1-alpha) is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin [taken from NCBI Entrez Gene (Gene ID: 6950)].
Description (Vector)
TCP1 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.
Gene ID
6950
Gene Name (eCommerce)
t-complex 1
Gene Name (Vector)
t-complex 1
Gene Symbol
TCP1
HGNC ID
HGNC:11655
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1671
ORF Size (bp)
1671 bp
Protein Name (eCommerce)
T-complex protein 1 subunit alpha
RefSeq ID
NM_030752
RefSeq Synonyms
NM_030752, NM_001008897, BC000665,
Research Areas
Cytoskeleton,Golgi Apparatus,Metabolism/Metabolic Process,Protein Folding,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
T-complex protein 1 subunit alpha (TCP1-alpha) is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin [taken from NCBI Entrez Gene (Gene ID: 6950)].
UniGene ID
Hs.363137
UniProt ID (eCommerce)
P17987

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.