human TCOF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TCOF1.
shAAV-225236
AAV-h-TCOF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TCOF1 (treacle ribosome biogenesis factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MFD1; TCS; TCS1; treacle
Description (Vector)
TCOF1 encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6949
Gene Name (Vector)
treacle ribosome biogenesis factor 1
Gene Symbol
TCOF1
HGNC ID
HGNC:11654
ORF Size (aa)
2877
ORF Size (bp)
2877 bp
RefSeq ID
NM_000356
RefSeq Synonyms
NM_001195141, NM_001135245, NM_001135244, NM_001135243, NM_001008657, NM_000356, BC033093, BC014559, BC011764,
Species
human
UniGene ID
Hs.605019
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.