human TCN2 shRNA silencing AAV

Name 
AAV-h-TCN2-shRNA
Cat No 
shAAV-225235
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TCN2.

shAAV-225235
AAV-h-TCN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TCN2 (transcobalamin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII
Description (Vector)
TCN2 encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
Gene ID
6948
Gene Name (Vector)
transcobalamin 2
Gene Symbol
TCN2
HGNC ID
HGNC:11653
ORF Size (aa)
1284
ORF Size (bp)
1284 bp
RefSeq ID
NM_000355
RefSeq Synonyms
NM_001184726, NM_000355, BC011239, BC001176,
Species
human
UniGene ID
Hs.417948

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.