human RPL11 shRNA silencing AAV

Name 
AAV-h-RPL11-shRNA
Cat No 
shAAV-225195
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPL11.

shAAV-225195
AAV-h-RPL11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL11 (ribosomal protein L11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
60S ribosomal protein L11; cell growth-inhibiting protein 34; CLL-associated antigen KW-12; DBA7; GIG34; L11; large ribosomal subunit protein uL5; uL5
Description (eCommerce)
60S ribosomal protein L11 (RPL11) binds to 5S ribosomal RNA (by similarity). RPL11 is required for rRNA maturation and formation of the 60S ribosomal subunits. RPL11 promotes nucleolar location of PML [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62913].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6135
Gene Name (eCommerce)
ribosomal protein L11
Gene Name (Vector)
ribosomal protein L11
Gene Symbol
RPL11
HGNC ID
HGNC:10301
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
534
Protein Name (eCommerce)
60S ribosomal protein L11
RefSeq ID
NM_000975
RefSeq Synonyms
NM_001199802, NM_000975, BC018970,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,p53 Signaling,RNA Binding,RNA Processing,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
60S ribosomal protein L11 (RPL11) binds to 5S ribosomal RNA (by similarity). RPL11 is required for rRNA maturation and formation of the 60S ribosomal subunits. RPL11 promotes nucleolar location of PML [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62913].
UniGene ID
Hs.15535
UniProt ID (eCommerce)
P62913

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.