human TCEB1 shRNA silencing AAV

Name
AAV-h-TCEB1-shRNA

Cat No
shAAV-225189

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ELOC.

shAAV-225189

AAV-h-TCEB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ELOC (elongin C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EloC; elongin 15 kDa subunit; elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII; SIII p15; TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); transcription elongation factor B polypeptide 1; transcription elongation factor B subunit 1

Description (eCommerce)

TCEB1 is the elongin C subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identifie [taken from NCBI Entrez Gene (Gene ID: 6921)].

Description (Vector)

TCEB1 encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Gene ID

6921

Gene Name (eCommerce)

elongin C

Gene Name (Vector)

elongin C

Gene Symbol

ELOC

HGNC ID

HGNC:11617

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

339

Protein Name (eCommerce)

Transcription elongation factor B polypeptide 1

RefSeq ID

NM_005648

RefSeq Synonyms

NM_005648, NM_001204864, NM_001204863, NM_001204862, NM_001204861, NM_001204860, NM_001204859, NM_001204858, NM_001204857, BC100283, BC100028, BC093065, BC013809,

Research Areas

Antigen Processing and Presentation,Cancer,Cell Biology,Gene Expression,HIF-1 Signaling,Hypoxia,Immunology,Kidney Cancer,Signal Transduction,Transcription Factor/Regulator,Ubiquitination

Research Areas (Faceted)

cancer,cell_biology,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.554594

UniProt ID (eCommerce)

Q15369

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.