human TACC3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TACC3.
shAAV-224892
AAV-h-TACC3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TACC3 (transforming acidic coiled-coil containing protein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ERIC1; ERIC-1; transforming acidic coiled-coil-containing protein 3
Description (eCommerce)
Transforming acidic coiled-coil-containing protein 3 (TACC3) plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. It is involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. TACC3 may be involved in the control of cell growth and differentiation and may contribute to cancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6A5].
Description (Vector)
TACC3 encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
Gene ID
10460
Gene Name (eCommerce)
transforming acidic coiled-coil containing protein 3
Gene Name (Vector)
transforming acidic coiled-coil containing protein 3
Gene Symbol
TACC3
HGNC ID
HGNC:11524
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2517
ORF Size (bp)
2517 bp
Protein Name (eCommerce)
Transforming acidic coiled-coil-containing protein 3
RefSeq ID
NM_006342
RefSeq Synonyms
NM_006342, BC111771, BC106071,
Research Areas
Cell Cycle,Cytoskeleton,Neurobiology,Neurodevelopment,Neurogenesis,RNA Transport,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Transforming acidic coiled-coil-containing protein 3 (TACC3) plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. It is involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. TACC3 may be involved in the control of cell growth and differentiation and may contribute to cancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6A5].
UniGene ID
Hs.104019
UniProt ID (eCommerce)
Q9Y6A5
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.