human SYTL2 shRNA silencing AAV

Name
AAV-h-SYTL2-shRNA

Cat No
shAAV-224865

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SYTL2.

shAAV-224865

AAV-h-SYTL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SYTL2 (synaptotagmin like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2; SLP2A

Description (Vector)

SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene ID

54843

Gene Name (Vector)

synaptotagmin like 2

Gene Symbol

SYTL2

HGNC ID

HGNC:15585

ORF Size (aa)

2808

ORF Size (bp)

2808 bp

RefSeq ID

NM_032379

RefSeq Synonyms

NM_206930, NM_206929, NM_206928, NM_206927, NM_032943, NM_032379, NM_001289610, NM_001289609, NM_001289608, NM_001162953, NM_001162952, NM_001162951, BC144115, BC144114, BC136450,

Species

human

UniGene ID

Hs.369520

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.