human SYK shRNA silencing AAV

p72-Syk; spleen tyrosine kinase; tyrosine-protein kinase SYK

SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.

SYK encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

6850

spleen associated tyrosine kinase

spleen associated tyrosine kinase

SYK

HGNC:11491

9606.0

1839

1839 bp

Tyrosine-protein kinase SYK

NM_003177

NM_003177, NM_001174168, NM_001174167, NM_001135052, BC011399, BC002962, BC001645,

Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiovascular,CD95/FAS Signaling,Cytokine Signaling,EPO Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,NF-kB Signaling,PI3K/Akt Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,VEGF Signaling,Viral Carcinogenesis

cardiovascular,cancer,developmental_biology,signal_transduction,immunology,infectious_disease,immunology,signal_transduction,cell_biology,neurobiology,signal_transduction,immunology,signal_transduction,cancer,infectious_disease

human

SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.

Hs.371720

P43405