human STX4 shRNA silencing AAV

Name 
AAV-h-STX4-shRNA
Cat No 
shAAV-224666
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human STX4.

shAAV-224666
AAV-h-STX4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STX4 (syntaxin 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
p35-2; renal carcinoma antigen NY-REN-31; STX4A; syntaxin 4A (placental); syntaxin-4
Description (eCommerce)
Syntaxin 4 is a plasma membrane t-SNARE protein that mediates docking of transport vesicles. Syntaxin 4 is necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, syntaxin 4 may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). It may also play a role in docking of synaptic vesicles at presynaptic active zones [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12846].
Gene ID
6810
Gene Name (eCommerce)
syntaxin 4
Gene Name (Vector)
syntaxin 4
Gene Symbol
STX4
HGNC ID
HGNC:11439
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
894
ORF Size (bp)
894 bp
Protein Name (eCommerce)
Syntaxin-4
RefSeq ID
NM_004604
RefSeq Synonyms
NM_004604, NM_001272096, NM_001272095, BC002436,
Research Areas
EGFR Signaling,Golgi Apparatus,Insulin Signaling,Neurobiology,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Syntaxin 4 is a plasma membrane t-SNARE protein that mediates docking of transport vesicles. Syntaxin 4 is necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, syntaxin 4 may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). It may also play a role in docking of synaptic vesicles at presynaptic active zones [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12846].
UniGene ID
Hs.83734
UniProt ID (eCommerce)
Q12846

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.