human STRADB shRNA silencing AAV

Name
AAV-h-STRADB-shRNA

Cat No
shAAV-224634

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human STRADB.

shAAV-224634

AAV-h-STRADB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STRADB (STE20-related kinase adaptor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038

Description (Vector)

STRADB encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

55437

Gene Name (Vector)

STE20-related kinase adaptor beta

Gene Symbol

STRADB

HGNC ID

HGNC:13205

ORF Size (aa)

1257

ORF Size (bp)

1257 bp

RefSeq ID

NM_018571

RefSeq Synonyms

NM_018571, NM_001206864, BC090871, BC008302,

Species

human

UniGene ID

Hs.652338

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.