human STIM1 shRNA silencing AAV

Name
AAV-h-STIM1-shRNA

Cat No
shAAV-224566

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human STIM1.

shAAV-224566

AAV-h-STIM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STIM1 (stromal interaction molecule 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D11S4896E; GOK; IMD10; STRMK; stromal interaction molecule 1; TAM; TAM1

Description (eCommerce)

Stromal interaction molecule 1 (STIM1) a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13586].

Description (Vector)

STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. STIM1 may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. STIM1 is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.

Gene ID

6786

Gene Name (eCommerce)

stromal interaction molecule 1

Gene Name (Vector)

stromal interaction molecule 1

Gene Symbol

STIM1

HGNC ID

HGNC:11386

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2058

ORF Size (bp)

2058 bp

Protein Name (eCommerce)

Stromal interaction molecule 1

RefSeq ID

NM_003156

RefSeq Synonyms

NM_003156, NM_001277962, NM_001277961, BC021300,

Research Areas

B-cell Receptor Signaling,Cytoskeleton,Immunology,Signal Transduction,T-cell Receptor Signaling,Transport

Research Areas (Faceted)

signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology

Species

human

Target Sentence

UniGene ID

Hs.501735

UniProt ID (eCommerce)

Q13586

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.