human ST5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ST5.
shAAV-224463
AAV-h-ST5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ST5 (suppression of tumorigenicity 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DENND2B; HTS1; p126
Description (Vector)
ST5 was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
Gene ID
6764
Gene Name (Vector)
suppression of tumorigenicity 5
Gene Symbol
ST5
HGNC ID
HGNC:11350
ORF Size (aa)
3414
ORF Size (bp)
3414 bp
RefSeq ID
NM_005418
RefSeq Synonyms
NM_213618, NM_139157, NM_005418, BC036655,
Species
human
UniGene ID
Hs.117715
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.