human SRPK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SRPK2.
shAAV-224353
AAV-h-SRPK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SRPK2 (SRSF protein kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
serine kinase SRPK2; serine/arginine-rich protein-specific kinase 2; serine/arginine-rich splicing factor kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SFRSK2; SR protein kinase 2; SR-protein-specific kinase 2; SRSF protein kinase 2
Description (eCommerce)
Serine/arginine rich protein-specific kinase 2 (SRPK2) phosphorylates RS domain-containing proteins, such as SFRS1 and SFRS2 on serine residues. SRPK2 plays a role in spliceosome assembly and in mediating the trafficking of splicing factors. SRPK2 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P78362].
Gene ID
6733
Gene Name (eCommerce)
SRSF protein kinase 2
Gene Name (Vector)
SRSF protein kinase 2
Gene Symbol
SRPK2
HGNC ID
HGNC:11306
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2067
ORF Size (bp)
2067 bp
Protein Name (eCommerce)
SRSF protein kinase 2
RefSeq ID
NM_182691
RefSeq Synonyms
NM_182692, NM_182691, NM_001278273, BC068547, BC035214,
Research Areas
Angiogenesis,Apoptosis,Cell Cycle,Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,Kinase/Phosphatase,mRNA Processing,mRNA Splicing,Neurobiology,Neurodevelopment,RNA Processing,Signal Transduction,Spliceosome
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Serine/arginine rich protein-specific kinase 2 (SRPK2) phosphorylates RS domain-containing proteins, such as SFRS1 and SFRS2 on serine residues. SRPK2 plays a role in spliceosome assembly and in mediating the trafficking of splicing factors. SRPK2 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P78362].
UniGene ID
Hs.285197
UniProt ID (eCommerce)
P78362
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.