human SRPK1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SRPK1.
shAAV-224352
AAV-h-SRPK1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SRPK1 (SRSF protein kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Serine/arginine-rich protein-specific kinase 1; serine/arginine-rich splicing factor kinase 1; serine/threonine-protein kinase SRPK1; SFRS protein kinase 1; SFRSK1; SR-protein-specific kinase 1; SRSF protein kinase 1
Description (eCommerce)
Serine/arginine rich protein-specific kinase 1 (SRPK1) plays a central role in the regulatory network for splicing by controlling the intranuclear distribution of splicing factors in interphase cells and the re-organization of nuclear speckles during mitosis. During metaphase, SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues. SRPK1 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96SB4].
Description (Vector)
SRPK1 encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.
Gene ID
6732
Gene Name (eCommerce)
SRSF protein kinase 1
Gene Name (Vector)
SRSF protein kinase 1
Gene Symbol
SRPK1
HGNC ID
HGNC:11305
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1968
ORF Size (bp)
1968 bp
Protein Name (eCommerce)
SRSF protein kinase 1
RefSeq ID
NM_003137
RefSeq Synonyms
NM_003137, BC038292,
Research Areas
Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,Kinase/Phosphatase,mRNA Processing,mRNA Splicing,RNA Processing,Signal Transduction,Spliceosome
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,infectious_disease,immunology,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Serine/arginine rich protein-specific kinase 1 (SRPK1) plays a central role in the regulatory network for splicing by controlling the intranuclear distribution of splicing factors in interphase cells and the re-organization of nuclear speckles during mitosis. During metaphase, SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues. SRPK1 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96SB4].
UniGene ID
Hs.443861
UniProt ID (eCommerce)
Q96SB4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.