human SREBF2 shRNA silencing AAV

Name
AAV-h-SREBF2-shRNA

Cat No
shAAV-224322

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SREBF2.

shAAV-224322

AAV-h-SREBF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SREBF2 (sterol regulatory element binding transcription factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bHLHd2; class D basic helix-loop-helix protein 2; SREBP2; SREBP-2; sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2

Description (eCommerce)

Sterol regulatory element binding transcription factor 2 (SREBP2) is a transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain [taken from NCBI Entrez Gene (Gene ID: 6721].

Description (Vector)

SREBF2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Gene ID

6721

Gene Name (eCommerce)

sterol regulatory element binding transcription factor 2

Gene Name (Vector)

sterol regulatory element binding transcription factor 2

Gene Symbol

SREBF2

HGNC ID

HGNC:11290

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2046

ORF Size (bp)

2046 bp

Protein Name (eCommerce)

Sterol regulatory element-binding protein 2

RefSeq ID

NM_004599

RefSeq Synonyms

NM_004599, BC056158, BC051385,

Research Areas

Aging,Golgi Apparatus,Metabolism/Metabolic Process,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,developmental_biology,metabolism,signal_transduction,transcription_translation

Species

human

Target Sentence

Sterol regulatory element binding transcription factor 2 (SREBP2) is a transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain [taken from NCBI Entrez Gene (Gene ID: 6721].

UniGene ID

Hs.443258

UniProt ID (eCommerce)

Q12772

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.