human SREBF1 shRNA silencing AAV

Name 
AAV-h-SREBF1-shRNA
Cat No 
shAAV-224320
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SREBF1.

shAAV-224320
AAV-h-SREBF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SREBF1 (sterol regulatory element binding transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bHLHd1; SREBP-1c; SREBP1; SREBP1a
Description (Vector)
SREBF1 encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. SREBF1 is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
6720
Gene Name (Vector)
sterol regulatory element binding transcription factor 1
Gene Symbol
SREBF1
HGNC ID
HGNC:11289
ORF Size (aa)
3534
ORF Size (bp)
3534 bp
RefSeq ID
NM_004176
RefSeq Synonyms
NM_004176, NM_001321096, NM_001005291, BC063281, BC057388,
Species
human
UniGene ID
Hs.592123

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.