human SQSTM1 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-224302
Availability:
4-5 weeks
Name:
AAV-h-SQSTM1-shRNA
This is an AAV expressing shRNA for silencing of Human SQSTM1.
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- SQSTM1
- Gene Name
- sequestosome 1
- Gene ID
- 8878
- Gene Synonyms
- A170; DMRV; FTDALS3; NADGP; OSIL; p60; p62; p62B; PDB3; ZIP3
- ORF Size
- 1071 bp
- RefSeq#
- NM_003900
- Gene Description
- SQSTM1 encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
- UniGene ID
- Hs.437277
- HGNC ID
- HGNC:11280
Related Products
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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