human SPR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPR.
shAAV-224239
AAV-h-SPR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPR (sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SDR38C1
Description (Vector)
SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
Gene ID
6697
Gene Name (Vector)
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Gene Symbol
SPR
HGNC ID
HGNC:11257
ORF Size (aa)
786
RefSeq ID
NM_003124
RefSeq Synonyms
NM_003124, BC017310,
Species
human
UniGene ID
Hs.301540
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.