human SPPL2B shRNA silencing AAV

Name
AAV-h-SPPL2B-shRNA

Cat No
shAAV-224236

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SPPL2B.

shAAV-224236

AAV-h-SPPL2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPPL2B (signal peptide peptidase like 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IMP-4; IMP4; PSH4; PSL1

Description (Vector)

SPPL2B encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

56928

Gene Name (Vector)

signal peptide peptidase like 2B

Gene Symbol

SPPL2B

HGNC ID

HGNC:30627

ORF Size (aa)

1536

ORF Size (bp)

1536 bp

RefSeq ID

NM_152988

RefSeq Synonyms

NM_152988, NM_001077238, BC093046, BC028391, BC001788,

Species

human

UniGene ID

Hs.330742

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.