human SPP1 shRNA silencing AAV

Name
AAV-h-SPP1-shRNA

Cat No
shAAV-224233

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SPP1.

shAAV-224233

AAV-h-SPP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SPP1 (secreted phosphoprotein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BNSP; BSPI; ETA-1; OPN

Description (Vector)

SPP1 is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

6696

Gene Name (Vector)

secreted phosphoprotein 1

Gene Symbol

SPP1

HGNC ID

HGNC:11255

ORF Size (aa)

864

RefSeq ID

NM_000582

RefSeq Synonyms

NM_001251830, NM_001251829, NM_001040060, NM_001040058, NM_000582, BC093033, BC022844, BC017387, BC007016,

Species

human

UniGene ID

Hs.313

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.