human SPG21 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SPG21.
shAAV-224162
AAV-h-SPG21-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SPG21 (spastic paraplegia 21 (autosomal recessive, Mast syndrome)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACP33; BM-019; GL010; MAST
Description (Vector)
SPG21 was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
Gene ID
51324
Gene Name (Vector)
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Gene Symbol
SPG21
HGNC ID
HGNC:20373
ORF Size (aa)
927
RefSeq ID
NM_016630
RefSeq Synonyms
NM_016630, NM_001127890, NM_001127889, BC000244,
Species
human
UniGene ID
Hs.242458
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.